A NEW EFFICIENT METHOD FOR THE PREPARATION OF 2-FLUORO-N-PROPYLNORAPOMORPHINE

被引：17

作者：

BERENYI, S

HOSZTAFI, S

MAKLEIT, S

机构：

[1] LAJOS KOSSUTH UNIV,DEPT ORGAN CHEM,H-4010 DEBRECEN,HUNGARY

[2] ALKALOIDA CHEM FACTORY,H-4440 TISZAVASVARI,HUNGARY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 20期

关键词：

D O I：

10.1039/p19920002693

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of the highly efficient, selective dopamine D2 agonist, 2-fluoro-N-propylnorapo-morphine 1 has been accomplished, involving the transformation of thebaine 13 into 6-fluoro-6-demethoxythebaine 10, followed by sequential N-demethylation, N-alkylation, rearrangement with methanesulfonic acid into the apocodeine derivative 17, and subsequent 0-demethylation with boron tribromide.

引用

页码：2693 / 2694

页数：2

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