WATER/N-OCTANOL PARTITION-COEFFICIENTS OF 1,2-DITHIOLE-3-THIONES

被引：24

作者：

BONA, M

BOUDEVILLE, P

ZEKRI, O

CHRISTEN, MO

BURGOT, JL

机构：

[1] UFR SCI PHARMACEUT & BIOL,DEPT ETUD PHYSICOCHIM & BIOCINET PHARMACOSYST,CHIM ANALYT LAB,F-35043 RENNES,FRANCE

[2] SOLVAY PHARMA,LTM,F-92151 SURESNES,FRANCE

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1995年 / 84卷 / 09期

关键词：

D O I：

10.1002/jps.2600840914

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Water/n-octanol partition coefficients (log P) for 33 1,2-dithiole-3-thiones and for 18 1,2-dithiol-3-ones were determined by RP-HPLC measurement of the concentration of the solute in aqueous solution after equilibrium. Depending on the nature of the substituents (alkyl or aryl) and their position(s) (4, 5, or both) on the dithiole nucleus, some peculiar behavior's were revealed. Therefore, different fragmental constants containing the 1,2-dithiole-3-thione nucleus were inferred in order to calculate in a complementary work, a priori, the log P values of new dithiolethiones and dithiolones

引用

页码：1107 / 1112

页数：6

共 43 条

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