ARACHIDONIC-ACID AUGMENTS POTASSIUM CURRENTS IN RAT NEOCORTICAL NEURONS

被引：20

作者：

ZONA, C

PALMA, E

PELLERIN, L

AVOLI, M

机构：

[1] MCGILL UNIV,MONTREAL NEUROL INST,DEPT NEUROL & NEUROSURG,MONTREAL H3A 2B4,QUEBEC,CANADA

[2] UNIV ROMA TOR VERGATA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,I-00173 ROME,ITALY

[3] UNIV LAUSANNE,INST PHYSIOL,CH-1005 LAUSANNE,SWITZERLAND

来源：

NEUROREPORT | 1993年 / 4卷 / 04期

关键词：

POTASSIUM CURRENTS; ARACHIDONIC ACID; RAT NEOCORTEX; PATCH CLAMP;

D O I：

10.1097/00001756-199304000-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE analysed the effects induced by arachidonic acid on voltage-dependent outward currents generated by rat neocortical neurones in culture in the presence of Na+ and Ca2+ channel blockers. These currents, recorded with whole-cell voltage-clamping techniques, were presumably carried by K+ and were characterized by an early transient and a late persistent component. Extracellular application of arachidonic acid (50 muM) enhanced both components of the voltage-dependent K+ response by 15-29% (n > 20 cells). These effects were reversible and not observed when a low dose (50 muM) of indomethacin was present in the bath (n = 7 cells). We conclude that one or more of the arachidonic acid metabolites of the cyclooxygenase pathway might be involved in the modulation of outward currents in neocortical cells in culture.

引用

页码：359 / 362

页数：4

共 25 条

[11] ARACHIDONIC-ACID METABOLITES AS INTRACELLULAR MODULATORS OF THE G-PROTEIN-GATED CARDIAC K+ CHANNEL [J].