THE RAC AND RHO PATHWAYS AS A SOURCE OF DRUG TARGETS FOR RAS-MEDIATED MALIGNANCIES

The small GTP-binding proteins Rac and Rho are key control elements in the reorganization of the actin cytoskeleton induced by growth factors or oncogenic Ras. It has been established recently that Rac and Rho also play a crucial role in Ras transformation. This suggests that the elements in the pathways regulated by Rac and Rho are valid drug targets for cancer therapy. Several important components of these signaling pathways have now been identified.