INHIBITION OF THE ATPASE ACTIVITY OF P-GLYCOPROTEIN BY PORPHYRIN PHOTOSENSITIZATION OF MULTIDRUG-RESISTANT CELLS IN-VITRO

被引:10
作者
GIBSON, SL [1 ]
ALSHAWI, MK [1 ]
SENIOR, AE [1 ]
HILF, R [1 ]
机构
[1] UNIV ROCHESTER, SCH MED & DENT, DEPT BIOCHEM, ROCHESTER, NY 14642 USA
关键词
D O I
10.1111/j.1751-1097.1995.tb08628.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effectiveness of photodynamic therapy against P-glycoprotein ATPase activity in multidrug-resistant cells was studied. Chinese hamster ovary AUXB1 (drag-sensitive) and CR1R12 (multidrug-resistant) cell lines were compared with respect to uptake of C-14-polyhematoporphyrin and porphyrin photosensitization. Phototoxicity of Photofrin(R) was similar in both cell lines, and no major differences in uptake or efflux of C-14-polyhematoporphyrin were observed. Porphyrin photosensitization in vitro of CR1R12 cells or isolated plasma membranes from these cells caused inhibition of P-glycoprotein ATPase activity. Application of porphyrin photosensitization at a sublethal level to CR1R12 cells resulted in a small but significant increase in adriamycin-induced cytotoxicity. The hydrophobic ''picket-fence'' porphyrin, meso-tetrakis-(o-propionamidophenyl)porphyrin,alpha,alpha,alpha,beta-isomer, was more inhibitory toward P-glycoprotein ATPase activity than the two less hydrophobic porphyrins tetraphenylporphine tetrasulfonate and Photofrin(R).
引用
收藏
页码:390 / 396
页数:7
相关论文
共 40 条
[11]   THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE [J].
ENDICOTT, JA ;
LING, V .
ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :137-171
[12]   DETECTION OF P-GLYCOPROTEIN ISOFORMS BY GENE-SPECIFIC MONOCLONAL-ANTIBODIES [J].
GEORGES, E ;
BRADLEY, G ;
GARIEPY, J ;
LING, V .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) :152-156
[13]   INVITRO PHOTOSENSITIZATION OF TUMOR-CELL ENZYMES BY PHOTOFRIN-II ADMINISTERED INVIVO [J].
GIBSON, SL ;
MURANT, RS ;
CHAZEN, MD ;
KELLY, ME ;
HILF, R .
BRITISH JOURNAL OF CANCER, 1989, 59 (01) :47-53
[14]   EFFECTS OF PHOTODYNAMIC THERAPY ON XENOGRAFTS OF HUMAN MESOTHELIOMA AND RAT MAMMARY-CARCINOMA IN NUDE-MICE [J].
GIBSON, SL ;
FOSTER, TH ;
FEINS, RH ;
RAUBERTAS, RF ;
FALLON, MA ;
HILF, R .
BRITISH JOURNAL OF CANCER, 1994, 69 (03) :473-481
[15]   MULTIDRUG RESISTANCE IN HUMAN CANCER [J].
GOLDSTEIN, LJ ;
PASTAN, I ;
GOTTESMAN, MM .
CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, 1992, 12 (03) :243-253
[16]   EXPRESSION OF A MULTIDRUG RESISTANCE GENE IN HUMAN CANCERS [J].
GOLDSTEIN, LJ ;
GALSKI, H ;
FOJO, A ;
WILLINGHAM, M ;
LAI, SL ;
GAZDAR, A ;
PIRKER, R ;
GREEN, A ;
CRIST, W ;
BRODEUR, GM ;
LIEBER, M ;
COSSMAN, J ;
GOTTESMAN, MM ;
PASTAN, I .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (02) :116-124
[17]   HOW DOES PHOTODYNAMIC THERAPY WORK [J].
HENDERSON, BW ;
DOUGHERTY, TJ .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1992, 55 (01) :145-157
[18]  
HILF R, 1986, CANCER RES, V46, P211
[19]   P-GLYCOPROTEIN - MULTIDRUG-RESISTANCE AND A SUPERFAMILY OF MEMBRANE-ASSOCIATED TRANSPORT PROTEINS [J].
JURANKA, PF ;
ZASTAWNY, RL ;
LING, V .
FASEB JOURNAL, 1989, 3 (14) :2583-2592
[20]  
KAMIMOTO Y, 1989, J BIOL CHEM, V264, P11693