INSIGHTS DERIVED FROM THE STRUCTURES OF THE SER/THR PHOSPHATASES CALCINEURIN AND PROTEIN PHOSPHATASE-1

被引：60

作者：

LOHSE, DL

DENU, JM

DIXON, JE

机构：

来源：

STRUCTURE | 1995年 / 3卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0969-2126(01)00234-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structures of serine/threonine phosphatases provide the basis for understanding their inhibition by physiologically relevant compounds such as microcystin, cyclosporin and FK506. THe structures also highlight the importance of a common sequence motif found in a large family of metal-containing enzymes involved in phosphatase ester hydrolysis.

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页码：987 / 990

页数：4

相关论文

共 24 条

[1] CONSERVATION ANALYSIS AND STRUCTURE PREDICTION OF THE PROTEIN SERINE/THREONINE PHOSPHATASES - SEQUENCE SIMILARITY WITH DIADENOSINE TETRAPHOSPHATASE FROM ESCHERICHIA-COLI SUGGESTS HOMOLOGY TO THE PROTEIN PHOSPHATASES [J].

BARTON, GJ ;

COHEN, PTW ;

BARFORD, D .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 220 (01) :225-237

[2]

Boyer P. D., 1986, ENZYMES, V17

[3] TARGETS OF IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEXES ARE DISTINCT HIGHLY CONSERVED REGIONS OF CALCINEURIN-A [J].

CARDENAS, ME ;

MUIR, RS ;

BREUDER, T ;

HEITMAN, J .

EMBO JOURNAL, 1995, 14 (12) :2772-2783

[4] THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES [J].

COHEN, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 1989, 58 :453-508

[5] DISCOVERY OF A PROTEIN PHOSPHATASE-ACTIVITY ENCODED IN THE GENOME OF BACTERIOPHAGE-LAMBDA - PROBABLE IDENTITY WITH OPEN READING FRAME 221 [J].

COHEN, PTW ;

COHEN, P .

BIOCHEMICAL JOURNAL, 1989, 260 (03) :931-934

[6] PHOSPHORYLATION AND INACTIVATION OF PROTEIN PHOSPHATASE-1 BY CYCLIN-DEPENDENT KINASES [J].

DOHADWALA, M ;

SILVA, EFDE ;

HALL, FL ;

WILLIAMS, RT ;

CARBONAROHALL, DA ;

NAIRN, AC ;

GREENGARD, P ;

BERNDT, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6408-6412

[7] A PHOSPHATASE BY ANY OTHER NAME - FROM PROSTHETIC GROUP REMOVING ENZYME TO PHOSPHORYLASE-PHOSPHATASE [J].

FISCHER, EH ;

BRAUTIGAN, DL .

TRENDS IN BIOCHEMICAL SCIENCES, 1982, 7 (01) :3-4

[8] 3-DIMENSIONAL STRUCTURE OF THE CATALYTIC SUBUNIT OF PROTEIN SERINE/THREONINE PHOSPHATASE-1 [J].

GOLDBERG, J ;

HUANG, HB ;

KWON, YG ;

GREENGARD, P ;

NAIRN, AC ;

KURIYAN, J .

NATURE, 1995, 376 (6543) :745-753

[9] X-RAY STRUCTURE OF CALCINEURIN INHIBITED BY THE IMMUNOPHILIN IMMUNOSUPPRESSANT FKBP12-FK506 COMPLEX [J].

GRIFFITH, JP ;

KIM, JL ;

KIM, EE ;

SINTCHAK, MD ;

THOMSON, JA ;

FITZGIBBON, MJ ;

FLEMING, MA ;

CARON, PR ;

HSIAO, K ;

NAVIA, MA .

CELL, 1995, 82 (03) :507-522

[10] INHIBITORS OF PROTEIN PHOSPHATASE-1 AND PHOSPHATASE-2A - 2 OF THE MAJOR SERINE THREONINE PROTEIN PHOSPHATASES INVOLVED IN CELLULAR-REGULATION [J].

HOLMES, CFB ;

BOLAND, MP .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (06) :934-943