INSIGHTS DERIVED FROM THE STRUCTURES OF THE SER/THR PHOSPHATASES CALCINEURIN AND PROTEIN PHOSPHATASE-1

被引：60

作者：

LOHSE, DL

DENU, JM

DIXON, JE

机构：

来源：

STRUCTURE | 1995年 / 3卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0969-2126(01)00234-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structures of serine/threonine phosphatases provide the basis for understanding their inhibition by physiologically relevant compounds such as microcystin, cyclosporin and FK506. THe structures also highlight the importance of a common sequence motif found in a large family of metal-containing enzymes involved in phosphatase ester hydrolysis.

引用

页码：987 / 990

页数：4

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