HIGH-RESOLUTION X-RAY-DIFFRACTION STUDY OF THE COMPLEX BETWEEN ENDOTHIAPEPSIN AND AN OLIGOPEPTIDE INHIBITOR - THE ANALYSIS OF THE INHIBITOR BINDING AND DESCRIPTION OF THE RIGID BODY SHIFT IN THE ENZYME

被引:107
作者
SALI, A [1 ]
VEERAPANDIAN, B [1 ]
COOPER, JB [1 ]
FOUNDLING, SI [1 ]
HOOVER, DJ [1 ]
BLUNDELL, TL [1 ]
机构
[1] PFIZER INC,DEPT MED CHEM,GROTON,CT 06340
关键词
D O I
10.1002/j.1460-2075.1989.tb08340.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:2179 / 2188
页数:10
相关论文
共 48 条
  • [1] 3-DIMENSIONAL STRUCTURE OF HUMAN RENIN
    AKAHANE, K
    UMEYAMA, H
    NAKAGAWA, S
    MORIGUCHI, I
    HIROSE, S
    IIZUKA, K
    MURAKAMI, K
    [J]. HYPERTENSION, 1985, 7 (01) : 3 - 12
  • [2] ANDREEVA NS, 1984, J BIOL CHEM, V259, P1353
  • [3] 3-DIMENSIONAL STRUCTURE, SPECIFICITY AND CATALYTIC MECHANISM OF RENIN
    BLUNDELL, T
    SIBANDA, BL
    PEARL, L
    [J]. NATURE, 1983, 304 (5923) : 273 - 275
  • [4] ON THE RATIONAL DESIGN OF RENIN INHIBITORS - X-RAY STUDIES OF ASPARTIC PROTEINASES COMPLEXED WITH TRANSITION-STATE ANALOGS
    BLUNDELL, TL
    COOPER, J
    FOUNDLING, SI
    JONES, DM
    ATRASH, B
    SZELKE, M
    [J]. BIOCHEMISTRY, 1987, 26 (18) : 5585 - 5590
  • [5] BLUNDELL TL, 1985, ASPARTIC PROTEINASES, P151
  • [6] 3-DIMENSIONAL STRUCTURE OF THE COMPLEX OF THE RHIZOPUS-CHINENSIS CARBOXYL PROTEINASE AND PEPSTATIN AT 2.5-A RESOLUTION
    BOTT, R
    SUBRAMANIAN, E
    DAVIES, DR
    [J]. BIOCHEMISTRY, 1982, 21 (26) : 6956 - 6962
  • [7] BOTT R, 1983, 8TH P AM PEPT S ROCK, P531
  • [8] CONSTRUCTION OF A MODEL FOR THE 3-DIMENSIONAL STRUCTURE OF HUMAN RENAL RENIN
    CARLSON, W
    KARPLUS, M
    HABER, E
    [J]. HYPERTENSION, 1985, 7 (01) : 13 - 26
  • [9] CHEN KCS, 1972, J BIOL CHEM, V247, P2566
  • [10] HYDROPHOBIC BONDING AND ACCESSIBLE SURFACE-AREA IN PROTEINS
    CHOTHIA, C
    [J]. NATURE, 1974, 248 (5446) : 338 - 339