COEXPOSURE TO GASOLINE VAPOR DECREASES BENZENE METABOLISM IN FISCHER-344 RATS

被引：10

作者：

TRAVIS, CC

FOX, MT

SIMMONS, WM

LYON, BF

机构：

[1] OAK RIDGE NATL LAB,DIV HLTH & SAFETY RES,RISK ANAL SECT,OAK RIDGE,TN 37831

[2] OAK RIDGE NATL LAB,DIV ENVIRONM & HLTH PROTECT,OAK RIDGE,TN 37831

来源：

TOXICOLOGY LETTERS | 1992年 / 62卷 / 2-3期

关键词：

PHYSIOLOGICALLY-BASED PHARMACOKINETICS MODELING; BENZENE; GASOLINE VAPOR; COEXPOSURE; GAS UPTAKE;

D O I：

10.1016/0378-4274(92)90026-G

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The metabolic interactions of benzene and gasoline vapor were investigated in male Fischer-344 rats. A closed chamber gas-uptake exposure system was used to obtain inhalation uptake curves for benzene alone and benzene in the presence of gasoline vapor. Exposure to benzene as a component of gasoline vapor resulted in a decrease of benzene metabolism. A physiologically based pharmacokinetic model of benzene metabolism was used to quantitatively determine the extent of the inhibitory effect of gasoline vapor on benzene metabolism. This observed inhibitory effect cannot be accounted for by the presence of toluene in gasoline vapor.

引用

页码：231 / 240

页数：10

共 19 条

[11] INVIVO METABOLIC INTERACTIONS OF BENZENE AND TOLUENE [J].