IBOTENIC ACID LESIONS OF MEDIAL PREFRONTAL CORTEX AUGMENT SWIM-STRESS-INDUCED LOCOMOTION

被引：36

作者：

JASKIW, GE ^{[1
]}

WEINBERGER, DR ^{[1
]}

机构：

[1] NIMH, INTRAMURAL RES PROGRAM, CLIN BRAIN DISORDERS BRANCH, NIMH RES CTR, WASHINGTON, DC 20032 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 41卷 / 03期

关键词：

PREFRONTAL CORTEX; IBOTENIC ACID; STRESS; SWIM; LOCOMOTION; DOPAMINE; RAT;

D O I：

10.1016/0091-3057(92)90380-X

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Locomotor activity of rats with sham or ibotenic acid lesions of the medial prefrontal cortex (MPFC) was assessed after animals were exposed to a 15-min swim or control stress. Swim-stress-induced locomotor activity was augmented in the MPFC-lesioned rats. These and other data suggest that lesions of the MPFC are followed by an exaggeration of the normal behavioral response to stress. Dysregulation of dopamine transmission in the basal ganglia may be involved.

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收藏

页码：607 / 609

页数：3

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