ENANTIOSELECTIVE SYNTHESIS AND ANTIELASTASE ACTIVITY OF 1,3,4-TRISUBSTITUTED AND 3,4-DISUBSTITUTED BETA-LACTAM ANTIBIOTICS

被引：8

作者：

ADONIAS, M

ANAYA, J

CAMARA, J

CANET, E

GATEAUOLESKER, A

GERO, SD

GRANDE, M

HERNANDO, JIM

机构：

[1] UNIV SALAMANCA,DEPT QUIM ORGAN,E-37008 SALAMANCA,SPAIN

[2] INST RECH INT SERVIER,F-92150 SURESNES,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80714-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and elastase inhibitory properties of 1,3,4-trisubstituted and 3,4-disubstituted 2-azetidinones are described. Nine of the synthesized derivatives showed elastase inhibitory activities and four of them were specific against human leukocyte elastase (HLE). 2-Deoxy-2-dithianyl-3,4;5,6-di-O-isopropylidene-D-2-glucosyl group attached to the beta-lactam nitrogen atom is related to the specificity against HLE.

引用

页码：2547 / 2552

页数：6

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