STEREOSELECTIVE APPROACH TO OPTICALLY PURE SYN 2-AMINO ALCOHOL DERIVATIVES

被引：31

作者：

DEBLAS, J ^{[1
]}

CARRETERO, JC ^{[1
]}

DOMINGUEZ, E ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,FAC CIENCIAS,DEPT QUIM,E-28049 MADRID,SPAIN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)60741-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly stereoselective procedure for the preparation of a variety of syn 2-amino alcohol derivatives from enantiopure E-gamma-hydroxy-alpha,beta-unsaturated phenyl sulfones is described. The method is based on an intramolecular carbamate cyclization, followed by functionalization at alpha-position by reaction of the sulfonyl carbanion with electrophiles, and subsequent elimination of the sulfonyl group.

引用

页码：4603 / 4606

页数：4

共 23 条

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