STUDY OF ANTISENSE OLIGONUCLEOTIDE PHOSPHOROTHIOATES CONTAINING SEGMENTS OF OLIGODEOXYNUCLEOTIDES AND 2'-O-METHYLOLIGORIBONUCLEOTIDES

被引：52

作者：

METELEV, V

LISZIEWICZ, J

AGRAWAL, S

机构：

[1] HYBRIDON INC,WORCESTER,MA 01605

[2] WORCESTER FDN EXPTL BIOL INC,SHREWSBURY,MA 01545

[3] NCI,TUMOR CELL BIOL LAB,BETHESDA,MD 20892

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(01)80842-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antisense oligonucleotide phosphorothioates have been designed, which contain segments of oligodeoxynucleotide and 2'-O-methyloligoribonucleotides and studied for their biophysical and biochemical properties. Oligonucleotide phosphorothioates containing segments of 2'-O-methyloligoribonucleotides at both 3'- and 5'-ends show increased nuclease resistance, bind more strongly to complementary RNA targets, activate RNase H and show increased inhibition of human immunodeficiency virus type 1 replication in infected cells.

引用

页码：2929 / 2934

页数：6

共 26 条

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