HALICYLINDRAMIDES A-C, ANTIFUNGAL AND CYTOTOXIC DEPSIPEPTIDES FROM THE MARINE SPONGE HALICHONDRIA-CYLINDRATA

被引：58

作者：

LI, HY ^{[1
]}

MATSUNAGA, S ^{[1
]}

FUSETANI, N ^{[1
]}

机构：

[1] UNIV TOKYO,FAC AGR,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 38卷 / 02期

关键词：

D O I：

10.1021/jm00002a015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Halicylindramides A-C (1-3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.

引用

页码：338 / 343

页数：6

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