1-(1-NAPHTHYL)ETHYLAMINE AND DERIVATIVES THEREOF AS CHIRAL MODIFIERS IN THE ENANTIOSELECTIVE HYDROGENATION OF ETHYL PYRUVATE OVER PT-ALUMINA

被引:57
作者
HEINZ, T
WANG, GZ
PFALTZ, A
MINDER, B
SCHURCH, M
MALLAT, T
BAIKER, A
机构
[1] UNIV BASEL,INST ORGAN CHEM,CH-4056 BASEL,SWITZERLAND
[2] ETH ZURICH,DEPT CHEM ENGN & IND CHEM,CH-8092 ZURICH,SWITZERLAND
关键词
D O I
10.1039/c39950001421
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Catalytic quantities of (R)- or (S)-1-(1-naphthyl)ethylamine induce up to 82% e.e. in the hydrogenation of ethyl pyruvate over Pt-alumina, the actual modifier responsible for enantioselection being the secondary amine resulting from imine formation with ethyl pyruvate and subsequent reduction of the C=N bond; a series of related derivatives has been prepared by reductive amination and tested as chiral modifiers.
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页码:1421 / 1422
页数:2
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