INDUCTION OF APOLIPOPROTEIN-E EXPRESSION DURING ERYTHROID-DIFFERENTIATION OF HUMAN K562 LEUKEMIA-CELLS

被引：3

作者：

CRESPO, P

DELGADO, MD

GOMEZCASARES, MT

CUADRADO, MA

RICHARD, C

LEON, J

机构：

[1] UNIV CANTABRIA,DEPT BIOL MOLEC,SANTANDER,SPAIN

[2] UNIV CANTABRIA,INST ESTUD AVANZADOS BIOL MOLEC,CSIC,SANTANDER,SPAIN

[3] HOSP UNIV MARQUES VALDECILLA,SERV HEMATOL,E-39011 SANTANDER,SPAIN

来源：

LEUKEMIA RESEARCH | 1993年 / 17卷 / 09期

关键词：

APOLIPOPROTEIN-E; K562-CELLS; ERYTHROID DIFFERENTIATION; BETA-ARABINOFURANOSYLCYTOSINE; HYDROXYUREA; TPA;

D O I：

10.1016/0145-2126(93)90111-W

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Apolipoprotein E (ApoE) is the only apolipoprotein that is expressed in extrahepatic tissues. ApoE expression was studied in leukemia K562 cells differentiated towards erythroid or myelomonocytic lineages. When K562 cells were differentiated into the erythroid lineage by addition either of 1-beta-D-arabinofuranosylcytosine or hydroxyurea, an increase in ApoE mRNA and protein was detected. A weaker ApoE induction was also observed during phorbol ester-induced myelomonocytic differentiation. Previous work has associated ApoE expression to monocytic differentiation. The findings reported here indicate that ApoE overexpression is not associated with a specific lineage in myeloid differentiation and that may play a role in erythroid differentiation.

引用

页码：771 / 776

页数：6

共 31 条

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