LITHIUM GAMMA-LINOLENATE-INDUCED CYTOTOXICITY AGAINST CELLS CHRONICALLY INFECTED WITH HIV-1

被引：6

作者：

KINCHINGTON, D ^{[1
]}

RANDALL, S ^{[1
]}

WINTHER, M ^{[1
]}

HORROBIN, D ^{[1
]}

机构：

[1] EFAMOL RES INST,KENTVILLE B4N 4H8,NS,CANADA

来源：

FEBS LETTERS | 1993年 / 330卷 / 02期

关键词：

HIV; LIPID PEROXIDATION; SYNCYTIUM INHIBITION;

D O I：

10.1016/0014-5793(93)80277-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lithium gamma-linolenate (Li-GLA), was evaluated for its activity in selectively killing H9 cells chronically infected with HIV-1RF. After 4 days incubation with Li-GLA approximately 90% of the H9RF cells were non-viable compared to 20% of uninfected H9 cells. The efficacy of the Li-GLA, in preferentially killing HIV infected cells also correlates with lipid peroxidation, as measured by the intracellular thiobarbituric acid-reactive material content. The addition of an antioxidant (vitamin E) to the culture medium reduced the toxicity of Li-GLA. These data indicate that this selective killing effect of cells chronically infected with HIV may be due to the enhanced extent of lipid peroxidation of the added Li-GLA.

引用

页码：219 / 221

页数：3