ADDITION OF AMINO ESTERS TO THIIRANIUM ION INTERMEDIATES - A NOVEL-APPROACH TO THE SYNTHESIS OF NEW POTENTIAL AMINOPEPTIDASE INHIBITORS

被引：13

作者：

GILL, DM

PEGG, NA

RAYNER, CM

机构：

[1] UNIV LEEDS, SCH CHEM, LEEDS LS2 9JT, W YORKSHIRE, ENGLAND

[2] GLAXO GRP RES LTD, MED CHEM 1, GREENFORD UB6 0HE, MIDDX, ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 45期

关键词：

D O I：

10.1016/0040-4039(95)01741-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of amino esters for the selective nucleophilic trapping of thiiranium ion intermediates generated in situ from homochiral 2,3-epoxy sulfides, allows synthetic access to a new class of compounds, structurally related to alpha-thiolbestatin and other known potent aminopeptidase inhibitors.

引用

页码：8327 / 8330

页数：4

共 29 条

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