THE EFFECT OF INTERLEUKIN-1 ON THE THYROID-GLAND

被引：39

作者：

RASMUSSEN, AK

FELDTRASMUSSEN, U

BENDTZEN, K

机构：

[1] Medical department P and medical department TTA, State University Hospital, Copenhagen

来源：

AUTOIMMUNITY | 1993年 / 16卷 / 02期

关键词：

THYROCYTE CULTURES; CYTOKINES; IL-1; IL-6; THYROIDITIS;

D O I：

10.3109/08916939308993319

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.

引用

页码：141 / 148

页数：8

共 56 条

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