THE EFFECT OF INTERLEUKIN-1 ON THE THYROID-GLAND

被引：39

作者：

RASMUSSEN, AK

FELDTRASMUSSEN, U

BENDTZEN, K

机构：

[1] Medical department P and medical department TTA, State University Hospital, Copenhagen

来源：

AUTOIMMUNITY | 1993年 / 16卷 / 02期

关键词：

THYROCYTE CULTURES; CYTOKINES; IL-1; IL-6; THYROIDITIS;

D O I：

10.3109/08916939308993319

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inhibitory effect of interleukin (IL)-1 on thyroid cell functions, including cAMP and thyroglobulin production, is well documented. Recently, IL-1 was shown to enhance the production of IL-6 from thyrocytes, and IL-1 receptors were demonstrated on normal thyroid cells. The origin of IL-1 could be from infiltrating monocytes/-macrophages, endothelial cells as well as from the thyrocytes themselves. Thus, IL-1 activated thyrocyte may participate directly in the immunological process by reacting to and producing immunoinflammatory cytokines.

引用

页码：141 / 148

页数：8

共 56 条

[31]

Fujii T., Sato K., Ozawa M., Kasono K., Imamura H., Kanaji Y., Et al., Effect of interleukin-1 (IL-1) on thyroid hormone metabolism in mice: Stimulation by IL-1 of iodothyronine 5′-deiodinating activity (type I) in the liver, Endocrinol, 124, pp. 167-174, (1989)

[32]

Enomoto T., Sugawa H., Kosugi S., Inoue D., Mori T., Imura H., Prolonged effects of recombinant human interleukin-1α on mouse thyroid function, Endocrinol, 127, pp. 2322-2327, (1990)

[33]

Hermus R.M.M., Sweep C.G.J., Meer van der M.J.M., Ross H.A., Smals A.G.H., Benraad T.J., Et al., Continuous infusion of interleukin-1β induces a nonthyroidal illness syndrome in the rat, Endocrinol, 131, pp. 2139-2146, (1992)

[34]

Kawabe Y., Eguchi K., Shimomura C., Mine M., Otsubo T., Ueki Y., Et al., Interleukin-1 production and action in thyroid tissue, J Clin Endocrinol Metab, 68, pp. 1174-1183, (1989)

[35]

Mine M., Tramontano D., Chin W.C., Ingbar S.H., Interleukin 1 stimulates thyroid cell growth and increases the concentration of the c-myc proto-oncogene mRNA in thyroid follicular cells in culture, Endocrinol, 120, pp. 1212-1214, (1987)

[36]

Weetman A.P., Rees A.J., Synergistic effects of recombinant tumour necrosis factor and interferon-gamma on rat thyroid cell growth and Ia antigen expression, Immunol, 63, pp. 285-289, (1988)

[37]

Asakawa H., Hanafusa, Oda Y., Katsura H., Miyagawa J.-I., Mashita K., Et al., Human recombinant interleukin 1 inhibits TSH-stimulated morphological changes in thyroid follicles cultured as semi-organs, Acta Endocrinol (Copenh), 125, pp. 80-85, (1991)

[38]

McLachlan S.M., Pegg C.A.S., Atherton M.C., Middleton S.L., Dickinson A., Clark F., Et al., The thyroid microenvironment in autoimmune thyroid disease: Effects of TSH and lymphokines on thyroid lymphocytes and thyroid cells, Acta Endocrinol (Copenh), 281, pp. 125-132, (1987)

[39]

Matsunaga M., Eguchi K., Fukuda T., Tezuka H., Ueki Y., Kawabe Y., Et al., The effects of cytokines, antithyroidal drugs and glucocorticoids on phagocytosis by thyroid cells, Acta Endocrinol (Copenh), 119, pp. 413-419, (1988)

[40]

Svenson M., Kayser L., Hansen M.B., Ramussen A.K., Bendtzen K., Interleukin-1 receptors on human thyroid cells and on the rat thyroid cell line FRTL-5, Cytokine, 3, pp. 125-130, (1991)

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