CARDIOVASCULAR EFFECTS OF CENTRAL ADMINISTRATION OF CHOLINOMIMETICS IN ANESTHETIZED CATS

被引:13
作者
ALLY, A [1 ]
HARA, Y [1 ]
MURAYAMA, S [1 ]
机构
[1] CHIBA UNIV, SCH MED, DEPT PHARMACOL, INOHANA 1-8-1, CHIBA 260, JAPAN
关键词
PHYSOSTIGMINE; INTRACEREBROVENTRICULAR; VENTRAL MEDULLA; BLOOD PRESSURE; MUSCARINIC RECEPTORS; CAT;
D O I
10.1016/0028-3908(93)90099-O
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cardiovascular effects of central administration of cholinomimetics were investigated in anesthetized cats, to identify the site and mechanism of their action. Physostigmine, 10-100 mug, given by intracerebroventricular administration (i.c.v.) caused a dose-dependent reduction in blood pressure and renal sympathetic nerve discharges and no change in heart rate, which were antagonized by intravenous injection (i.v.) of atropine but not by methscopolamine or pirenzepine, given intravenously. Carbachol 3-30 mug (i.c.v.) reduced blood pressure and renal sympathetic nerve discharges and caused no change in heart rate. The M1 muscarinic agonist, McN-A-343, 100-1000 mug (i.c.v.) did not affect blood pressure, heart rate or renal sympathetic nerve discharges. Bilateral application of physostigmine, 10-100 mug/site on the ventral medullary surface, decreased blood pressure and renal sympathetic nerve discharges but not heart rate. Carbachol, 3-30 mug/site, caused reductions in blood pressure and renal sympathetic nerve discharges and no change in heart rate. Atropine, but not pirenzepine or methscopolamine, reversed the effects of physostigmine or carbachol. Treatment with McN-A-343, 100-1000 mug/site, did not alter blood pressure, heart mte or renal sympathetic nerve discharges. Under pretreatment with atropine into the ventral medulla but not pirenzepine, physostigmine, given intravenously, did not influence blood pressure. It is concluded that a cholinergic mechanism, concerned with a depressor response, is located on the ventral medulla. Muscarinic receptors of the non-M1 subtype, possibly M2, are related to this mechanism.
引用
收藏
页码:185 / 193
页数:9
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