SYNTHESIS OF C2-SYMMETRICAL AND PSEUDOSYMMETRIC HIV-1 PROTEASE INHIBITORS FROM D-MANNITOL AND D-ARABITOL

被引：41

作者：

CHENERA, B

BOEHM, JC

DREYER, GB

机构：

[1] Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)80256-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Facile stereocontrolled syntheses of the potent HIV-1 protease inhibitors 1 and 2 are described, employing a unified synthetic route from carbohydrate precursors.

引用

页码：219 / 222

页数：4

共 25 条

[11]

KEMPF DJ, 1990, Patent No. 402646

[12]

LEMERRER Y, 1987, HETEROCYCLES, V25, P541

[13] HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE EXPRESSED IN ESCHERICHIA-COLI BEHAVES AS A DIMERIC ASPARTIC PROTEASE [J].

MEEK, TD ;

DAYTON, BD ;

METCALF, BW ;

DREYER, GB ;

STRICKLER, JE ;

GORNIAK, JG ;

ROSENBERG, M ;

MOORE, ML ;

MAGAARD, VW ;

DEBOUCK, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (06) :1841-1845

[14] INHIBITION OF HIV-1 PROTEASE IN INFECTED LYMPHOCYTES-T BY SYNTHETIC PEPTIDE ANALOGS [J].

MEEK, TD ;

LAMBERT, DM ;

DREYER, GB ;

CARR, TJ ;

TOMASZEK, TA ;

MOORE, ML ;

STRICKLER, JE ;

DEBOUCK, C ;

HYLAND, LJ ;

MATTHEWS, TJ ;

METCALF, BW ;

PETTEWAY, SR .

NATURE, 1990, 343 (6253) :90-92

[15]

MEEK TD, 1990, DESIGN ANTIAIDS DRUG, V14, P225

[16]

Meienhofer J., 1979, PEPTIDES ANAL SYNTHE, V1, P263

[17] THE USE OF DIETHYL AZODICARBOXYLATE AND TRIPHENYLPHOSPHINE IN SYNTHESIS AND TRANSFORMATION OF NATURAL-PRODUCTS [J].

MITSUNOBU, O .

SYNTHESIS-STUTTGART, 1981, (01) :1-28

[18] TOTAL SYNTHESIS OF FK506 AND AN FKBP PROBE REAGENT, (C8,C9-(C-13)2)-FK506 [J].

NAKATSUKA, M ;

RAGAN, JA ;

SAMMAKIA, T ;

SMITH, DB ;

UEHLING, DE ;

SCHREIBER, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (14) :5583-5601

[19] 3-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1 [J].

NAVIA, MA ;

FITZGERALD, PMD ;

MCKEEVER, BM ;

LEU, CT ;

HEIMBACH, JC ;

HERBER, WK ;

SIGAL, IS ;

DARKE, PL ;

SPRINGER, JP .

NATURE, 1989, 337 (6208) :615-620

[20] HYDROXYETHYLAMINE ANALOGS OF THE P17/P24 SUBSTRATE CLEAVAGE SITE ARE TIGHT-BINDING INHIBITORS OF HIV PROTEASE [J].

RICH, DH ;

GREEN, J ;

TOTH, MV ;

MARSHALL, GR ;

KENT, SBH .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1285-1288

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