NEW FLUORINATED BIOCOMPATIBLE NONIONIC TELOMERIC AMPHIPHILES BEARING TRIHYDROXYMETHYL GROUPS

被引：18

作者：

PAVIA, AA

PUCCI, B

RIESS, JG

ZARIF, L

机构：

[1] FAC MED NICE,CNRS,CHIM MOLEC LAB,PARC VALROSE,F-06034 NICE,FRANCE

[2] FAC SCI AVIGNON,CHIM BIOORGAN LAB,F-84000 AVIGNON,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)80240-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New perfluoroalkylated telomeric surfactants derived from tris(hydroxymethyl)aminomethane were synthesized in two steps and 50% overall yield. These surfactants display significantly better surface activity and enhanced capacity to emulsify fluorocarbons compared to Pluronic F-68(R). Preliminary in vitro and in vivo evaluation (cell cultures, hemolysis, LD50 i.v. in mice) indicates that this type of compounds is remarkably non-toxic, and could find applications in preparations for biomedical uses including injectable fluorocarbon emulsions.

引用

页码：103 / 106

页数：4