HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF BETA-LACTAMS BY ADDITION OF TITANIUM ENOLATES OF 2-PYRIDYL THIOESTERS TO CHIRAL IMINES

被引：10

作者：

ANNUNZIATA, R

CINQUINI, M

COZZI, F

COZZI, PG

机构：

[1] UNIV MILAN,CTR CNR,VIA GOLGI 19,I-20133 MILAN,ITALY

[2] UNIV MILAN,DIPARTIMENTO CHIM ORGAN & IND,I-20133 MILAN,ITALY

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 08期

关键词：

DIASTEREOSELECTION; TITANIUM ENOLATES; THIOESTERS; IMINES; BETA-LACTAMS;

D O I：

10.1016/S0040-4039(00)91874-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition of titanium enolates of 2-pyridyl thioesters to chiral imines derived from alkoxy aldehydes occurs with good diastereofacial control, and opens a simple access to important carbapenem antibiotics.

引用

页码：1113 / 1116

页数：4

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