DIFFERENTIAL PATTERN OF BETA-AMYLOID PROTEIN DEPOSITION WITHIN CORTICAL SULCI AND GYRI IN ALZHEIMERS-DISEASE

被引：15

作者：

CLINTON, J

ROBERTS, GW

GENTLEMAN, SM

ROYSTON, MC

机构：

[1] CHARING CROSS & WESTMINSTER MED SCH,DEPT PSYCHIAT,ST DUNSTAN RD,LONDON W6 8RT,ENGLAND

[2] ST MARYS HOSP,SCH MED,IMPERIAL COLL,DEPT ANAT & CELL BIOL,LONDON,ENGLAND

[3] CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT,LONDON,ENGLAND

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1993年 / 19卷 / 03期

关键词：

ALZHEIMERS DISEASE; BETA-AMYLOID; IMAGE ANALYSIS; SULCUS; GYRUS; DISTRIBUTION PATTERN;

D O I：

10.1111/j.1365-2990.1993.tb00438.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have quantified the pattern of beta-amyloid protein (betaAP) deposition in the sulci and gyri of the frontal cortex in Alzheimer's disease. The distribution pattern in the frontal cortex gyri is unequivocally different from the pattern found in the frontal sulci. These findings, in conjunction with our previous studies, reflect a differential vulnerability between the sulci and the gyri with respect to Alzheimer's disease pathology, sulci being affected to a greater extent. It is probable that the different patterns of deposition relate to the underlying cytoarchitecture of the cortex.

引用

页码：277 / 281

页数：5

共 17 条

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