THE EFFICACY AND SAFETY OF GAMMA-LINOLENIC ACID IN THE TREATMENT OF INFANTILE ATOPIC-DERMATITIS

被引:35
作者
FIOCCHI, A
SALA, M
SIGNORONI, P
BANDERALI, G
AGOSTONI, C
RIVA, E
机构
[1] 5th Pediatric Department, University of Milan, Milan
关键词
GAMMA-LINOLENIC ACID; EVENING PRIMROSE OIL; ATOPIC DERMATITIS; ECZEMA;
D O I
10.1177/030006059402200103
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The efficacy and safety of gamma-linolenic acid in the treatment of atopic dermatitis was evaluated. The children (mean age, 11.4 months) with atopic dermatitis (mean duration, 8.56 months) were openly treated with 3 g/day gamma-linolenic acid, for 28 days. Clinical evaluations were carried out every 7 days, and parents were asked to keep a diary, recording details of symptoms of eczema every day. Blood chemistry and immunological tests were done before and after treatment. None of the children showed complete recovery of symptoms. A gradual improvement in erythema, excoriations and lichenification was seen; significant differences were shown for itching (P < 0.01), and the use of antihistamines (P < 0.01). A significant rise in the percentage of circulating CD8 was found. No side-effects were recorded. Dietetic and pharmacological approaches are the basis of the treatment of atopic dermatitis and gamma-linolenic acid appears to be a safe and efficient additional therapy for infants and young children.
引用
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页码:24 / 32
页数:9
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