THE EFFICACY AND SAFETY OF GAMMA-LINOLENIC ACID IN THE TREATMENT OF INFANTILE ATOPIC-DERMATITIS

被引：35

作者：

FIOCCHI, A

SALA, M

SIGNORONI, P

BANDERALI, G

AGOSTONI, C

RIVA, E

机构：

[1] 5th Pediatric Department, University of Milan, Milan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1994年 / 22卷 / 01期

关键词：

GAMMA-LINOLENIC ACID; EVENING PRIMROSE OIL; ATOPIC DERMATITIS; ECZEMA;

D O I：

10.1177/030006059402200103

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The efficacy and safety of gamma-linolenic acid in the treatment of atopic dermatitis was evaluated. The children (mean age, 11.4 months) with atopic dermatitis (mean duration, 8.56 months) were openly treated with 3 g/day gamma-linolenic acid, for 28 days. Clinical evaluations were carried out every 7 days, and parents were asked to keep a diary, recording details of symptoms of eczema every day. Blood chemistry and immunological tests were done before and after treatment. None of the children showed complete recovery of symptoms. A gradual improvement in erythema, excoriations and lichenification was seen; significant differences were shown for itching (P < 0.01), and the use of antihistamines (P < 0.01). A significant rise in the percentage of circulating CD8 was found. No side-effects were recorded. Dietetic and pharmacological approaches are the basis of the treatment of atopic dermatitis and gamma-linolenic acid appears to be a safe and efficient additional therapy for infants and young children.

引用

页码：24 / 32

页数：9

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