BLOOD TRANSFERRIN RECEPTOR EXPRESSION IN CHROMOSOMALLY ABNORMAL FETUSES

被引：14

作者：

THILAGANATHAN, B ^{[1
]}

MEHERHOMJI, NJ ^{[1
]}

NICOLAIDES, KH ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL,SCH MED,HARRIS BIRTHRIGHT RES CTR FETAL MED,LONDON WC2R 2LS,ENGLAND

来源：

PRENATAL DIAGNOSIS | 1995年 / 15卷 / 03期

关键词：

CORDOCENTESIS; FETAL BLOOD; TRANSFERRIN RECEPTOR; CD71; FLOW CYTOMETRY; CHROMOSOMAL ABNORMALITY;

D O I：

10.1002/pd.1970150313

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In a cross-sectional study of 13 chromosomally abnormal fetuses, umbilical venous blood was obtained by cordocentesis at 17-32 weeks' gestation. Fetal blood transferrin receptor (CD71) expression (mean 79.8 per cent, range=60-98 per cent) and nucleated red cell count (mean 10.4 x 10(9) per 1, range=1.0-25.0 x 10(9) per 1) were significantly higher than the appropriate normal mean for gestation (z=3.92, P < 0.0001 and z=3.69, P < 0.001, respectively). These haematological changes in chromosomally abnormal fetuses would facilitate their prenatal diagnosis by analysis of fetal nucleated red blood cells isolated from the maternal circulation on the basis of CD71 expression.

引用

页码：282 / 284

页数：3

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