RESOLUTION OF SECONDARY ALCOHOLS BY ENZYME-CATALYZED TRANSESTERIFICATION IN ALKYL CARBOXYLATES AS THE SOLVENT

被引：95

作者：

JANSSEN, AJM ^{[1
]}

KLUNDER, AJH ^{[1
]}

ZWANENBURG, B ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN,NSR CTR MOLEC STRUCT DESIGN & SYNTH,DEPT ORGAN CHEM,6525 ED NIJMEGEN,NETHERLANDS

来源：

TETRAHEDRON | 1991年 / 47卷 / 36期

关键词：

D O I：

10.1016/S0040-4020(01)88288-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Porcine Pancreatic Lipase (PPL)- and Mucor Esterase-catalyzed resolution of 1-phenylethanol 5 in four different alkyl carboxylate solvents, viz. methyl acetate, propionate and butyrate and ethyl acetate, was evaluated. The beneficial influence of the addition of molecular sieves 4 angstrom to the reaction mixture is demonstrated. A Mucor Esterase-catalyzed resolution of 5 on a 0.5 mol scale is described. The kinetic resolution of a large variety of secondary alcohols (5 - 22b) was investigated using both biocatalysts under the established optimal reaction conditions for substrate 5.

引用

页码：7645 / 7662

页数：18

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