SPERMINE INCREASES PAIRED-PULSE FACILITATION IN AREA CA1 OF HIPPOCAMPUS IN A CALCIUM-DEPENDENT MANNER

被引：18

作者：

FERCHMIN, PA ^{[1
]}

ETEROVIC, VA ^{[1
]}

RIVERA, EM ^{[1
]}

TEYLER, TJ ^{[1
]}

机构：

[1] NE OHIO UNIV, COLL MED, DEPT NEUROBIOL, ROOTSTOWN, OH 44272 USA

来源：

BRAIN RESEARCH | 1995年 / 689卷 / 02期

关键词：

SPERMINE; POLYAMINE; HIPPOCAMPAL SLICE; CA1; FIELD POTENTIAL; PAIRED-PULSE FACILITATION; CA2+ CHANNEL;

D O I：

10.1016/0006-8993(95)00568-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of spermine on neurotransmission was studied in area CA1 of the hippocampal slice preparation. Paired-pulse stimulation (20 ms interpulse interval) was delivered to stratum radiatum; the evoked field potential responses were recorded simultaneously from stratum radiatum and from stratum pyramidale. At mM and sub-mM concentrations, spermine decreased the slope of pEPSP in stratum radiatum and the area of the conditioning population spike in stratum pyramidale. Short-latency paired-pulse inhibition of the population spike was converted to facilitation by spermine. These effects of spermine resembled those observed at low calcium concentration. In addition, dose-response and input-output curves determined at various Ca2+ concentrations demonstrated that the depressant effects of spermine were larger at low Ca2+ levels. The results support the notion that spermine competitively blocks presynaptic voltage-sensitive Ca2+ channels, thus causing a decreased release of neurotransmitter. Since spermine is present in brain, it is likely that it is a natural modulator of Ca2+ channels.

引用

页码：189 / 196

页数：8

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