A GENE DIFFERENTIALLY EXPRESSED IN THE KIDNEY OF THE SPONTANEOUSLY HYPERTENSIVE RAT COSEGREGATES WITH INCREASED BLOOD-PRESSURE

被引：105

作者：

SAMANI, NJ

LODWICK, D

VINCENT, M

DUBAY, C

KAISER, MA

KELLY, MP

LO, M

HARRIS, J

SASSARD, J

LATHROP, M

SWALES, JD

机构：

[1] UNIV LEICESTER,DEPT MED,LEICESTER LE2 7LX,W YORKSHIRE,ENGLAND

[2] FAC PHARM LYON,DEPT PHYSIOL & PHARMACOL CLIN,CNRS,URA 1483,F-69373 LYON,FRANCE

[3] CTR ETUD POLYMORPHISM HUMAIN,INSERM,U358,F-75010 PARIS,FRANCE

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 92卷 / 02期

基金：

英国惠康基金;

关键词：

HYPERTENSION; GENETICS; KIDNEY; SPONTANEOUSLY HYPERTENSIVE RAT; GENE EXPRESSION;

D O I：

10.1172/JCI116616

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The role of the kidney in initiating hypertension has been much debated. Here we demonstrate that a recently identified gene of yet unknown function, termed S(A), which is differentially expressed in the kidney of the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive Wistar-Kyoto rats, accounting for 28 and 21 % of the genetic variability in systolic and diastolic blood pressures, respectively. Further, the genotype at this locus appears to determine the level of expression of the gene in the kidney. The findings provide strong evidence for a primary genetic involvement of the kidney in hypertension.

引用

页码：1099 / 1103

页数：5

共 33 条

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