PARABOLIC STRUCTURE-ACTIVITY-RELATIONSHIPS - A SIMPLE PHARMACOKINETIC MODEL

被引:15
作者
AARONS, L [1 ]
BELL, D [1 ]
WAIGH, R [1 ]
YE, Q [1 ]
机构
[1] UNIV MANCHESTER,INST SCI & TECHNOL,CTR CONTROL SYST,MANCHESTER M60 1QD,LANCS,ENGLAND
关键词
D O I
10.1111/j.2042-7158.1982.tb06217.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:746 / 749
页数:4
相关论文
共 9 条
[1]   KINETIC-ANALYSIS OF RELATIONSHIP BETWEEN PARTITION-COEFFICIENT AND BIOLOGICAL RESPONSE [J].
COOPER, ER ;
BERNER, B ;
BRUCE, RD .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (01) :57-59
[2]   LIPOPHILIC CHARACTER AND BIOLOGICAL-ACTIVITY OF DRUGS .2. PARABOLIC CASE [J].
HANSCH, C ;
CLAYTON, JM .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1973, 62 (01) :1-21
[3]  
KUBINYI H, 1976, ARZNEIMITTEL-FORSCH, V26, P1991
[4]   QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS .7. BILINEAR MODEL, A NEW MODEL FOR NONLINEAR DEPENDENCE OF BIOLOGICAL-ACTIVITY ON HYDROPHOBIC CHARACTER [J].
KUBINYI, H .
JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (05) :625-629
[5]  
LIPPOLD BC, 1975, ARZNEIMITTEL-FORSCH, V25, P843
[6]   ON PARABOLIC RELATIONSHIP BETWEEN DRUG POTENCY AND HYDROPHOBICITY [J].
MCFARLAND, JW .
JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1192-+
[7]  
PENNISTON JT, 1969, MOL PHARMACOL, V5, P333
[8]  
SEYDEL JK, 1982, PHARM THER, V18, P131
[9]  
VANDEWATERBEEMD H, 1980, EUR J MED CHEM, V15, P279