CRYSTAL-STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR-BB

被引：189

作者：

OEFNER, C

DARCY, A

WINKLER, FK

EGGIMANN, B

HOSANG, M

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,DEPT NEW TECHNOL,CH-4002 BASEL,SWITZERLAND

[2] F HOFFMANN LA ROCHE & CO LTD,DEPT PRECLIN RES & DEV,CH-4002 BASEL,SWITZERLAND

来源：

EMBO JOURNAL | 1992年 / 11卷 / 11期

关键词：

PLATELET-DERIVED GROWTH FACTOR; RECEPTOR BINDING DOMAINS; X-RAY STRUCTURE;

D O I：

10.1002/j.1460-2075.1992.tb05485.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of the homodimeric BB isoform of human recombinant platelet-derived growth factor (PDGF-BB) has been determined by X-ray analysis to 3.0 angstrom resolution. The polypeptide chain is folded into two highly twisted antiparallel pairs of beta-strands and contains an unusual knotted arrangement of three intramolecular disulfide bonds. Dimerization leads to the clustering of three surface loops at each end of the elongated dimer, which most probably form the receptor recognition sites.

引用

页码：3921 / 3926

页数：6

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