STRUCTURE ACTIVITY RELATIONSHIPS OF DIHYDROFOLATE-REDUCTASE INHIBITORS

被引：183

作者：

BLANEY, JM

HANSCH, C

SILIPO, C

VITTORIA, A

机构：

[1] POMONA COLL, DEPT CHEM, CLAREMONT, CA 91711 USA

[2] UNIV CALIF SAN FRANCISCO, SCH PHARM, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USA

[3] UNIV NAPLES, FAC PHARM, INST PHARMACEUT & TOXICOL CHEM, I-80138 NAPLES, ITALY

来源：

CHEMICAL REVIEWS | 1984年 / 84卷 / 04期

关键词：

D O I：

10.1021/cr00062a002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：333 / 407

页数：75

共 495 条

[71] ANALOGS OF TETRAHYDROFOLIC ACID .25. 2,4-DIAMINO-6-PHENETHYLPTERIDINE AN INHIBITOR OF DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

HO, BT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (09) :1261-&

[72] ANALOGS OF TETRAHYDROFOLIC ACID .22. EFFECTS OF MODIFICATION OF BRIDGE BETWEEN PYRIMIDYL AND PHENYL MOIETIES OF 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL ON INHIBITION OF DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE 3 [J].

BAKER, BR ;

COWARD, JK .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (05) :714-&

[73] ANALOGS OF TETRAHYDROFOLIC ACID .11. - SYNTHESIS + ENZYMIC EVALUATION OF P- ( N-)2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYL ) CARBAMOYL METHYL ) AMINO ) BENZOYL-L-GLUTAMIC ACID [J].

BAKER, BR ;

SACHDEV, K .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (09) :1020-&

[74] ANALOGS OF TETRAHYDROFOLIC ACID .15. MODE OF BINDING OF 2,4-DIAMINOPYRIMIDINES TO FOLIC REDUCTASE + THYMIDYLATE SYNTHETASE [J].

BAKER, BR ;

HO, BT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (12) :1457-&

[75] DIFFERENTIAL BINDING TO HYDROPHOBIC BONDING REGION OF T2 PHAGE INDUCED ESCHERICHIA COLI B AND PIGEON LIVER DIHYDROFOLIC REDUCTASES [J].

BAKER, BR .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (05) :912-&

[76] IRREVERSIBLE ENZYME INHIBITORS .129. P-(4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZIN-1-YL)PHENYLPROPIONYLSULFANILYL FLUORIDE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE .V. EFFECTS OF SUBSTITUTION ON BENZENESULFONYL FLUORIDE MOIETY ON ISOZYME SPECIFICITY [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (04) :677-&

[77] IRREVERSIBLE ENZYME INHIBITORS .108. 6-(P-CHLOROACETYLANILINOMETHYL)-5-(P-CHLOROPHENYL)-2,4-DIAMINOPYRIMIDINE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

HUANG, PC ;

POGOLOTTI, AL .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1134-+

[78] ANALOGS OF TETRAHYDROFOLIC ACID .31. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .3. FURTHER OBSERVATIONS ON CONFORMATIONAL ASPECTS OF HYDROPHOBIC BONDING WITH SOME 5-ALKYL-2,4-DIAMINO-6-PYRIMIDINOLS [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :344-&

[79] ANALOGS OF TETRAHYDROFOLIC ACID .19. ON MODE OF BINDING OF PYRIMIDYL MOIETY OF N-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYLPROPIONYL)-P-AMINOBENZOYL-L-GLUTAMIC ACID TO 5,10-METHYLENETETRAHYDROFOLATE DEHYDROGENASE [J].

BAKER, BR ;

ALMAULA, PI .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1964, 1 (05) :263-&

[80] IRREVERSIBLE ENZYME INHIBITORS . 135 . EFFECT OF RING SUBSTITUTION ON SELECTIVE IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM L1210 MOUSE LEUKEMIA AND LIVER BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-(P-(P-FLUOROSULFONYLPHENYLUREIDO)PHENOXYMETHYL)PYRIMIDINE [J].

BAKER, BR ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :79-+

← 3 4 5 6 7 8 9 10 11 12 →