EFFECTS OF CALCITONIN GENE-RELATED PEPTIDE ON EXTRAPYRAMIDAL MOTOR SYSTEM

被引：22

作者：

CLEMENTI, G ^{[1
]}

GRASSI, M ^{[1
]}

VALERIO, C ^{[1
]}

PRATO, A ^{[1
]}

FIORE, CE ^{[1
]}

DRAGO, F ^{[1
]}

机构：

[1] UNIV CATANIA,SCH MED,DEPT MED PATHOL,I-95125 CATANIA,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 42卷 / 03期

关键词：

CGRP; CATALEPSY; HYPOMOTILITY; DOPAMINERGIC SYSTEM;

D O I：

10.1016/0091-3057(92)90153-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of central administration of calcitonin gene-related peptide (CGRP, 1 or 100 ng/rat) on behavioral and biochemical parameters related to the extrapyramidal motor system were investigated in male rats. The peptide-induced catalepsy occurred only at the dose of 100 ng/rat and hypomotility at both doses used. Calcitonin gene-related peptide increased haloperidol-induced catalepsy and decreased apomorphine-induced hypermotility at the doses of 1 and 100 ng/rat. Although these behaviors are related to dopamine, no significant change of striatal DA or DOPAC concentration were observed after central administration of the peptide. Other neurotransmitters may be directly or indirectly involved in these behavioral effects of CGRP.

引用

页码：545 / 548

页数：4

共 21 条

[1] ALTERNATIVE RNA PROCESSING IN CALCITONIN GENE-EXPRESSION GENERATES MESSENGER-RNAS ENCODING DIFFERENT POLYPEPTIDE PRODUCTS
AMARA, SG
JONAS, V
ROSENFELD, MG
ONG, ES
EVANS, RM
[J]. NATURE, 1982, 298 (5871) : 240 - 244
[2] ARGIOLAS A, 1978, EXPERIENTIA, V32, P739
[3] Bates R, 1984, BRIT J PHARMACOL, V82, P295
[4] BRAKKEE JH, 1979, LAB ANIM SCI, V29, P78
[5] HYPOPROLACTINEMIC ACTION OF CALCITONIN AND THE TUBEROINFUNDIBULAR DOPAMINERGIC SYSTEM
CLEMENTI, G
NICOLETTI, F
PATACCHIOLI, F
PRATO, A
PATTI, F
FIORE, CE
MATERA, M
SCAPAGNINI, U
[J]. JOURNAL OF NEUROCHEMISTRY, 1983, 40 (03) : 885 - 886
[6] DUNSTAN R, 1980, PHARM BIOCH BEHAV, V14, P168
[7] HYPOPROLACTINEMIC EFFECT OF CALCITONIN GENE-RELATED PEPTIDE IN THE RAT
ELIE, C
MOUKHTAR, MS
MILHAUD, G
CRESSENT, M
[J]. NEUROPEPTIDES, 1990, 16 (02) : 109 - 113
[8] FISHER JA, 1985, PEPTIDES S53, V6, P265
[9] DISTINCT BINDING-SITES FOR CALCITONIN GENE-RELATED PEPTIDE AND SALMON-CALCITONIN IN RAT CENTRAL-NERVOUS-SYSTEM
HENKE, H
TSCHOPP, FA
FISCHER, JA
[J]. BRAIN RESEARCH, 1985, 360 (1-2) : 165 - 171
[10] EFFECTS OF CALCITONIN GENE-RELATED PEPTIDE ON FOOD-INTAKE
KRAHN, DD
GOSNELL, BA
LEVINE, AS
MORLEY, JE
[J]. PEPTIDES, 1984, 5 (05) : 861 - 864

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