STRAND SCISSION IN DNA INDUCED BY L-DOPA IN THE PRESENCE OF CU(II)

被引：45

作者：

HUSAIN, S ^{[1
]}

HADI, SM ^{[1
]}

机构：

[1] ALIGARH MUSLIM UNIV,FAC LIFE SCI,DEPT BIOCHEM,ALIGARH 202002,UTTAR PRADESH,INDIA

来源：

FEBS LETTERS | 1995年 / 364卷 / 01期

关键词：

DNA CLEAVAGE; L-DOPA; COPPER; REACTIVE OXYGEN SPECIES;

D O I：

10.1016/0014-5793(95)00365-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been recently reported that L-DOPA and CuO(II) in the presence of H2O2 leads to extensive DNA damage. In this paper we show that L-DOPA in the presence of CuO alone can cause DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Fluorescence quenching studies indicate that L-DOPA is capable of binding to DNA.

引用

页码：75 / 78

页数：4

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