HISTAMINE-RELEASE FROM RAT MAST-CELLS INDUCED BY ECONAZOLE

被引：5

作者：

HANADA, S

OGA, S

机构：

[1] Department of Pharmacology, Instituto de Ciências Biomédicas, Universidade de São Paulo

来源：

GENERAL PHARMACOLOGY | 1991年 / 22卷 / 03期

关键词：

D O I：

10.1016/0306-3623(91)90015-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Econazole released histamine from rat mast cells in vitro. This response was not affected by the addition of calcium or by prior treatment of mast cells with EDTA or cromoglycate. 2. Rat mast cells treated with econazole were stained by the vital dye trypan blue. 3. The intradermal injection of econazole increased vascular permeability. This response was antagonized by chlorpheniramine and cyproheptadine. 4. Our results demonstrate that econazole releases histamine by the "nonselective" mechanism. It is suggested that econazole inflammatory effects may be due to histamine release from mast cells.

引用

页码：511 / 513

页数：3

共 16 条

[1] STUDIES ON MORPHOLOGICAL CHANGES AND HISTAMINE RELEASE INDUCED BY BEE VENOM N-DECYLAMINE AND HYPOTONIC SOLUTIONS IN RAT PERITONEAL MAST CELLS [J].