MASS-SPECTROMETRY OF LASER-DESORBED OLIGONUCLEOTIDES

被引：76

作者：

TANG, K ^{[1
]}

ALLMAN, SL ^{[1
]}

CHEN, CH ^{[1
]}

机构：

[1] OAK RIDGE NATL LAB, POB 2008, MS-6378, OAK RIDGE, TN 37831 USA

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1992年 / 6卷 / 06期

关键词：

D O I：

10.1002/rcm.1290060602

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Various matrices were used for laser-desorption ionization of mixtures of small DNA segments. Parent negative ions of 34-mer as well as other smaller single-stranded oligomers were observed for selected organic acids and dye compounds. Both positive and negative parent ions were observed with very little fragmentation. Effects of various matrices and the potential applications to DNA sequencing are briefly discussed.

引用

页码：365 / 368

页数：4

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