ROLE OF THE SEROTONERGIC SYSTEM IN THE FORCED SWIMMING TEST

被引：224

作者：

BORSINI, F

机构：

[1] Boehringer Ingelheim Italia S.p.A., 20131 Milano

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1995年 / 19卷 / 03期

关键词：

FORCED SWIMMING TEST; SEROTONIN; SEROTONERGIC DRUGS; BEHAVIOR; ANTIDEPRESSANTS; RAT; MOUSE;

D O I：

10.1016/0149-7634(94)00050-B

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effect of manipulations aimed at modifying the function of the 5-HT system has been reviewed. 5-HT uptake inhibitors are devoid of any activity in rats and induce an anti-immobility effect in mice. The so-called 5-HT1A agonists reduce the immobility time with some differences in mice and rats, mice being less sensitive. None of the procedure aimed at reducing 5-HT function reduced immobility time. Therefore, the 5-HT system does not play a tonic role in animals performing the forced swimming test. The involvement of possible brain regions mediating the anti-immobility effects of 5-HT mimetic drugs has been discussed.

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页码：377 / 395

页数：19

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