AMINO-ACID-SEQUENCE OF A MYOTOXIN FROM VENOM OF THE EASTERN DIAMONDBACK RATTLESNAKE (CROTALUS-ADAMANTEUS)

被引：22

作者：

SAMEJIMA, Y ^{[1
]}

AOKI, Y ^{[1
]}

MEBS, D ^{[1
]}

机构：

[1] UNIV FRANKFURT,ZENTRUM RECHTSMED,W-6000 FRANKFURT 1,GERMANY

来源：

TOXICON | 1991年 / 29卷 / 4-5期

关键词：

D O I：

10.1016/0041-0101(91)90020-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The complete amino acid sequence of a myotoxin isolated from Crotalus adamanteus venom (CAM-toxin) was determined. The total number of amino acid residues was 45, giving a mol. wt of 5202. The amino acid sequence was compared with those of previously determined Crotalus myotoxins. The CAM-toxin shows a surprisingly close relationship to those of peptide c (C. v. helleri), myotoxin a (C. v. viridis), crotamine (C. d. terrificus), myotoxin I and II (C. v. concolor) with homologies of approximately 98, 83, 90, 95 and 91%, respectively. The hydropathy profile of the CAM-toxin is almost identical to peptide c and myotoxin I, as can be assumed from the sequence homology. Despite the absence of any close sequence homology with the myotoxic phospholipase A2 enzymes, CAM-toxin contains a similar cationic myotoxic region at residues 2-10 as found in the other five myotoxic peptides.

引用

页码：461 / 468

页数：8

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