CDC25 PHOSPHATASES AS POTENTIAL HUMAN ONCOGENES

被引:509
作者
GALAKTIONOV, K
LEE, AK
ECKSTEIN, J
DRAETTA, G
MECKLER, J
LODA, M
BEACH, D
机构
[1] COLD SPRING HARBOR LAB, HOWARD HUGHES MED INST, COLD SPRING HARBOR, NY 11724 USA
[2] HARVARD UNIV, SCH MED, LAHEY CLIN MED CTR, BURLINGTON, MA 01805 USA
[3] MITOTIX, CAMBRIDGE, MA 02139 USA
[4] HARVARD UNIV, DEACONESS HOSP, SCH MED, DEPT PATHOL, BOSTON, MA 02215 USA
关键词
D O I
10.1126/science.7667636
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cyclin-dependent kinases (CDKs) are activated by CDC25 phosphatases, which remove inhibitory phosphate from tyrosine and threonine residues. In human cells, CDC25 proteins are encoded by a multigene family, consisting of CDC25A, CDC25B, and CDC25C. In rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either Ha-RAS(G12V) or loss of RB1 in oncogenic focus formation. Such transformants were highly aneuploid, grew in soft agar, and formed high-grade tumors in nude mice. Overexpression of CDC25B was detected in 32 percent of human primary breast cancers tested. The CDC25 phosphatases may contribute to the development of human cancer.
引用
收藏
页码:1575 / 1577
页数:3
相关论文
共 46 条
  • [1] ABNORMAL P53 IMMUNOREACTIVITY AND PROGNOSIS IN NODE-NEGATIVE BREAST CARCINOMAS WITH LONG-TERM FOLLOW-UP
    BOSARI, S
    LEE, AKC
    VIALE, G
    HEATLEY, GJ
    COGGI, G
    [J]. VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY, 1992, 421 (04) : 291 - 295
  • [2] CYTOPLASMIC ACCUMULATION OF P53 PROTEIN - AN INDEPENDENT PROGNOSTIC INDICATOR IN COLORECTAL ADENOCARCINOMAS
    BOSARI, S
    VIALE, G
    BOSSI, P
    MAGGIONI, M
    COGGI, G
    MURRAY, JJ
    LEE, AKC
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (09): : 681 - 687
  • [3] MICROVESSEL QUANTITATION AND PROGNOSIS IN INVASIVE BREAST-CARCINOMA
    BOSARI, S
    LEE, AKC
    DELELLIS, RA
    WILEY, BD
    HEATLEY, GJ
    SILVERMAN, ML
    [J]. HUMAN PATHOLOGY, 1992, 23 (07) : 755 - 761
  • [4] ACTIVATION OF MAP KINASE KINASE IS NECESSARY AND SUFFICIENT FOR PC12 DIFFERENTIATION AND FOR TRANSFORMATION OF NIH 3T3 CELLS
    COWLEY, S
    PATERSON, H
    KEMP, P
    MARSHALL, CJ
    [J]. CELL, 1994, 77 (06) : 841 - 852
  • [5] WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION
    ELDEIRY, WS
    TOKINO, T
    VELCULESCU, VE
    LEVY, DB
    PARSONS, R
    TRENT, JM
    LIN, D
    MERCER, WE
    KINZLER, KW
    VOGELSTEIN, B
    [J]. CELL, 1993, 75 (04) : 817 - 825
  • [6] CYCLIN - A PROTEIN SPECIFIED BY MATERNAL MESSENGER-RNA IN SEA-URCHIN EGGS THAT IS DESTROYED AT EACH CLEAVAGE DIVISION
    EVANS, T
    ROSENTHAL, ET
    YOUNGBLOM, J
    DISTEL, D
    HUNT, T
    [J]. CELL, 1983, 33 (02) : 389 - 396
  • [7] SPECIFIC ACTIVATION OF CDC25 TYROSINE PHOSPHATASES BY B-TYPE CYCLINS - EVIDENCE FOR MULTIPLE ROLES OF MITOTIC CYCLINS
    GALAKTIONOV, K
    BEACH, D
    [J]. CELL, 1991, 67 (06) : 1181 - 1194
  • [8] RAF1 INTERACTION WITH CDC25 PHOSPHATASE TIES MITOGENIC SIGNAL-TRANSDUCTION TO CELL-CYCLE ACTIVATION
    GALAKTIONOV, K
    JESSUS, C
    BEACH, D
    [J]. GENES & DEVELOPMENT, 1995, 9 (09) : 1046 - 1058
  • [9] GALAKTIONOV K, UNPUB
  • [10] TYROSINE PHOSPHORYLATION OF THE FISSION YEAST CDC2+ PROTEIN-KINASE REGULATES ENTRY INTO MITOSIS
    GOULD, KL
    NURSE, P
    [J]. NATURE, 1989, 342 (6245) : 39 - 45