EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATION OF GROWTH HORMONE-RELEASING FACTOR AND CORTICOTROPIN-RELEASING FACTOR ON SOMATOSTATIN SECRETION INTO RAT HYPOPHYSEAL PORTAL BLOOD

被引：49

作者：

MITSUGI, N ^{[1
]}

ARITA, J ^{[1
]}

KIMURA, F ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT PHYSIOL,3-9 FUKUURA,KANAZAWA KU,YOKOHAMA 236,JAPAN

来源：

NEUROENDOCRINOLOGY | 1990年 / 51卷 / 01期

关键词：

Corticotropin-releasing factor; Growth hormone-releasing factor; Hypophysial portal blood; Intracerebroventricular administration; Somatostatin;

D O I：

10.1159/000125322

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To clarify the regulatory mechanisms for the secretion of somatostatin (SRI F) from the hypothalamus, the effects of intracerebroventricular (i.c.v.) administration of growth hormone-releasing factor (GRF) and corticotropin-releasing factor (CRF) on SRIF secretion into hypophysial portal blood were examined in pentobarbital-anesthetized male rats. Neither the concentration of SRIF in portal plasma nor the secretion rate of SRIF was changed after i.c.v. administration of 0.9% saline. Administration of 10 ng or 5 mg human GRF i.c.v. produced a significant increase in the portal plasma concentration and secretion rate of SR1F. Likewise, 5 mg CRF significantly increased the portal plasma concentration and secretion rate of SRIF. These results suggest that the neuropeptides GRF and CRF centrally influence SRIF secretion into hypophysial portal blood. © 1990 S. Karger AG, Basel.

引用

页码：93 / 96

页数：4