KUPFFER CELLS CYTOTOXICITY AGAINST HEPATOMA-CELLS IS RELATED TO NITRIC-OXIDE

被引：19

作者：

AONO, K

ISOBE, K

NAKASHIMA, I

KONDO, S

MIYACHI, M

NIMURA, Y

机构：

[1] NAGOYA UNIV,SCH MED,DEPT IMMUNOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN

[2] NAGOYA UNIV,SCH MED,DEPT SURG 1,NAGOYA,AICHI 461,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously demonstrated that rat resting macrophages have cytotoxicity against tumor cells. In the current study we have performed an in vitro experiment to explore the mechanism of Kupffer cells-mediated cytotoxicity against hepatomas. The coculture of tumor cells with Kupffer cells (derived from rat livers) stimulated syngeneic and allogeneic Kupffer cells to produce nitric oxide. Kupffer cell-mediated cytotoxicity was paralleled to the amount of nitric oxide and was abolished by the addition of N-G-monomethyl-L-arginine. The ability to stimulate Kupffer cells to produce nitric oxide resided on the membranous fragment of tumor cells. (C) 1994 Academic Press, Inc.

引用

页码：1175 / 1181

页数：7