REGIOSPECIFIC SYNTHESIS OF 4-FLUORO-DELTA(4),3-KETO STEROIDS USING CESIUM FLUOROXYSULFATE

被引：11

作者：

HODSON, HF

MADGE, DJ

WIDDOWSON, DA

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM,LONDON SW7 2AY,ENGLAND

[2] WELLCOME RES LABS,DEPT MED CHEM,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 23期

关键词：

D O I：

10.1039/p19950002965

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regiospecific synthesis of two A-ring fluorinated steroids is described. Treatment of a 4-trimethylstannyl Delta(4),3-keto steroid with caesium fluoroxysulfate gave the corresponding fluorinated steroid in good yield; use of the N-fluorodiazabicyclic reagent, Selectfluor, as the fluorine source provides the same compounds in lower yield. The fluorination was found to be sufficiently rapid to be potentially useful in the synthesis of F-18 labelled steroids for PETT applications.

引用

页码：2965 / 2968

页数：4

共 22 条

[1]

Appelman E. H., 1986, INORG SYNTH, V24, P22

[2] SYNTHESIS OF ORGANOTRIALKYLSTANNANES - THE REACTION BETWEEN ORGANIC HALIDES AND HEXAALKYLDISTANNANES IN THE PRESENCE OF PALLADIUM COMPLEXES [J].