SUBSTITUTION OF THE METHYL-GROUPS WITH ETHYL GROUPS AT C-10 AND C-15 OF 2,3-OXIDOSQUALENE HALTS THE ENZYMATIC-REACTION OF OXIDOSQUALENE-LANOSTEROL CYCLASE AT THE MONOCYCLIC RING STAGE

被引：14

作者：

HOSHINO, T

ISHIBASHI, E

KANEKO, K

机构：

[1] NIIGATA COLL PHARM,NIIGATA 95021,JAPAN

[2] NIIGATA UNIV,FAC AGR,DEPT APPL BIOL CHEM,NIIGATA 95021,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 23期

关键词：

D O I：

10.1039/C39950002401

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incubation of the substrate analogue, (3S)-(E,E,E,E,E)-10,15-diethyl-2,6,19,23 6,10,14,18,22-pentaene (-)-1, with 2,3-oxidosqualene-lanosterol cyclase from pigs liver gave unprecedented cyclization products 2 and 3 having a monocyclic skeleton.

引用

页码：2401 / 2402

页数：2

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