HEPATOPROTECTIVE ACTIVITY IN THE RAT OF URSOLIC ACID ISOLATED FROM EUCALYPTUS HYBRID

被引：37

作者：

SHUKLA, B

VISEN, PKS

PATNAIK, GK

TRIPATHI, SC

SRIMAL, RC

DAYAL, R

DOBHAL, PC

机构：

[1] CENT DRUG RES INST, DIV PHARMACOL, LUCKNOW 226001, UTTAR PRADESH, INDIA

[2] FOREST RES INST, DEHRA DUN, INDIA

来源：

PHYTOTHERAPY RESEARCH | 1992年 / 6卷 / 02期

关键词：

URSOLIC ACID; SILYMARIN; HEPATIC DAMAGE; CHOLERETIC; HEPATOPROTECTIVE;

D O I：

10.1002/ptr.2650060205

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ursolic acid has been evaluated for its choleretic, anticholestatic and hepatoprotective activities in rats. It produced a dose-dependent (5-20 mg/kg) choleretic effect. Significant anticholestatic activity (27.9-100%) was observed against paracetamol (2.0 g/kg) induced cholestasis. The compound also showed a marked hepatoprotective activity against paracetamol and galactosamine (800 mg/kg) induced hepatotoxicity by reversing the altered values in viability of the isolated hepatocytes and the altered biochemical liver and serum parameters. The activity of ursolic acid compared well with the known hepatoprotective drug, silymarin.

引用

页码：74 / 79

页数：6

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