STEM-CELL ORIGINS OF LEUKEMIA AND CURABILITY

被引：74

作者：

GREAVES, MF

机构：

[1] Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, SW3 6JB

来源：

BRITISH JOURNAL OF CANCER | 1993年 / 67卷 / 03期

关键词：

D O I：

10.1038/bjc.1993.81

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is suggested that most childhood acute lymphoblastic leukaemias an some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemo-sensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells.

引用

收藏

页码：413 / 423

页数：11

相关论文

共 143 条

[71] EVIDENCE FROM POPULATION MIXING IN BRITISH NEW TOWNS 1946-85 OF AN INFECTIVE BASIS FOR CHILDHOOD LEUKEMIA [J].

KINLEN, LJ ;

CLARKE, K ;

HUDSON, C .

LANCET, 1990, 336 (8715) :577-582

[72] DIFFERENCE OF CELL LINEAGE EXPRESSION OF HEMATOPOIETIC PROGENITOR CELLS IN PHILADELPHIA-POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA AND CHRONIC MYELOGENOUS LEUKEMIA [J].

KITANO, K ;

SATO, Y ;

SUDA, T ;

MIURA, Y .

BRITISH JOURNAL OF HAEMATOLOGY, 1988, 70 (01) :21-26

[73]

Knudson A G Jr, 1977, Adv Hum Genet, V8, P1

[74] REARRANGEMENTS OF DNA MEDIATED BY TERMINAL TRANSFERASE [J].

KUNKEL, TA ;

GOPINATHAN, KP ;

DUBE, DK ;

SNOW, ET ;

LOEB, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (06) :1867-1871

[75]

LAJTHA LG, 1979, DIFFERENTIATION, V14, P23, DOI 10.1111/j.1432-0436.1979.tb01007.x

[76] CANCER - P53, GUARDIAN OF THE GENOME [J].

LANE, DP .

NATURE, 1992, 358 (6381) :15-16

[77] SURVIVAL OF HEMATOPOIETIC PROGENITORS IN THE G0 PERIOD OF THE CELL-CYCLE DOES NOT REQUIRE EARLY HEMATOPOIETIC REGULATORS [J].

LEARY, AG ;

HIRAI, Y ;

KISHIMOTO, T ;

CLARK, SC ;

OGAWA, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4535-4538

[78]

LEDOUARIN NM, 1978, COLD SPRING HARBOR C, V5, P5

[79] THE MECHANISM OF V(D)J RECOMBINATION - A BALANCE OF DIVERSITY, SPECIFICITY, AND STABILITY [J].

LIEBER, MR .

CELL, 1992, 70 (06) :873-876

[80] GERMINAL CENTER CELLS EXPRESS BCL-2 PROTEIN AFTER ACTIVATION BY SIGNALS WHICH PREVENT THEIR ENTRY INTO APOPTOSIS [J].

LIU, YJ ;

MASON, DY ;

JOHNSON, GD ;

ABBOT, S ;

GREGORY, CD ;

HARDIE, DL ;

GORDON, J ;

MACLENNAN, ICM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (08) :1905-1910

← 3 4 5 6 7 8 9 10 11 12 →