BONE-MINERAL DENSITY OF THE SPINE AND THE HIP MEASURED WITH DUAL-ENERGY X-RAY ABSORPTIOMETRY - NORMAL RANGE AND FRACTURE THRESHOLD FOR WESTERN-EUROPEAN (BELGIAN) POSTMENOPAUSAL FEMALES

被引：25

作者：

REGINSTER, JY

JANSSEN, C

DEROISY, R

ZEGELS, B

ALBERT, A

FRANCHIMONT, P

机构：

[1] Georgetown University Medical Center, Washington DC

[2] Centre Universitaire d'Investigation du Métabolisme Osseux et du Cartilage Articulaire, University of Liège, Liège, 4020

来源：

CLINICAL RHEUMATOLOGY | 1995年 / 14卷 / 01期

关键词：

OSTEOPOROSIS; MENOPAUSE; BONE MINERAL DENSITY; DUAL ENERGY; X-RAY ABSORPTIOMETRY;

D O I：

10.1007/BF02208087

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone mineral density (BMD) of the spine and the different regions of interest (ROI) of the hip were measured by dual energy X-ray absorptiometry in 278 healthy Belgian postmenopausal women and 93 postmenopausal type I osteoporotic females in order to: a) determine the normal range for lumbar and hip BMD values; b) define an ''hypothetical'' fracture threshold in this population; c) determine the preferential region to be considered for clinical use in type I osteoporosis. In the normal subjects, there is a negative relationship (<0.001) between age or time elapsed since menopause (Tm) and BMD measured at the level of the spine or at the ROI of the hip. For the spine, evidence of a curvilinear relationship was assessed. Regressions of BMD at the hip as a function of age or time elapsed since menopause, were best fitted by a linear relationship. In the population of postmenopausal women who have experienced a vertebral crush fracture, no relationships were observed between spine BMD and age or Tm but the osteoporotic women had a spine BMD significantly lower compared to age-matched normal controls: Z-score = -1.2 +/- 0.6 (mean +/- SD) (p < 0.0001). Fracture threshold calculated as the 90th percentile of spine BMD measured in osteoporotic patients was 0.840 g/cm(2), corresponding to the mean value -1 SD for a population of women aged 51 years.

引用

页码：68 / 75

页数：8

共 40 条

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