AN IMPROVED DIPHOSPHINE-IRIDIUM(I) CATALYST SYSTEM FOR THE ASYMMETRIC HYDROGENATION OF CYCLIC IMINES - PHTHALIMIDE AS AN EFFICIENT COCATALYST

被引：85

作者：

MORIMOTO, T

ACHIWA, K

机构：

[1] School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka-shi, 422

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 11期

关键词：

D O I：

10.1016/0957-4166(95)00351-O

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric hydrogenation of cyclic ketimines, 1-alkyl-3,4-dihydroisoquinolines 5a,b, was carried out with diphosphine-iridium(I) complex catalysts in the presence of various imides or amides as a co-catalyst. Remarkable effects of five-membered imides on the enantioselectivity and the catalytic activity were observed. The enantioselectivity with a BCPM 1-iridium(I) complex was much improved up to 93% ee by addition of phthalimide.

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页码：2661 / 2664

页数：4

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