EFFECT OF DIABETES ON THE ANTINOCICEPTIVE EFFECT OF BETA-ENDORPHIN

被引：15

作者：

KAMEI, J ^{[1
]}

KAWASHIMA, N ^{[1
]}

HITOSUGI, H ^{[1
]}

MISAWA, M ^{[1
]}

NAGASE, H ^{[1
]}

KASUYA, Y ^{[1
]}

机构：

[1] TORAY INDUSTRIES LTD,BASIC RES LABS,KAMAKURA,JAPAN

来源：

BRAIN RESEARCH | 1993年 / 619卷 / 1-2期

关键词：

DIABETES; BETA-ENDORPHIN; ANTINOCICEPTION; NALTRINDOLE; DAMGO; U-50,488H; DPDPE; MOUSE;

D O I：

10.1016/0006-8993(93)91597-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined whether streptozotocin-induced diabetes can modulate beta-endorphin-induced antinociception in mice. While beta-endorphin administered i.c.v. produced a dose-dependent inhibition of the tail-flick response in both diabetic and non-diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. The ED50 value of beta-endorphin administered i.cv. in diabetic mice was significantly lower than that in non-diabetic mice. The antinociceptive effects of beta-endorphin administered i.c.v. in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective delta-opioid receptor antagonist. Beta-Endorphin administered i.t. also produced a dose-dependent antinociception in both diabetic and non-diabetic mice. However, the ED50 value of beta-endorphin administered i.t. in diabetic mice was significantly higher than that in non-diabetic mice. The antinociceptive effect of beta-endorphin administered i.t. in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of nor-binaltorphimine, a selective kappa-opioid receptor antagonist. On the other hand, the antinociceptive potency of DPDPE, a selective delta-opioid agonist, administered i.t. is significantly increased in diabetic mice, as compared with non-diabetic mice, whereas, the antinociceptive potency of U-50,488H, a kappa-opioid receptor agonist, administered i.t. is significantly less than in non-diabetic mice. These results suggest that diabetes may modulate beta-endorphin-induced antinociception differently at the spinal and supraspinal levels.

引用

页码：76 / 80

页数：5

共 21 条

[1]

DEWEY WL, 1970, J PHARMACOL EXP THER, V175, P435

[2] C-FRAGMENT OF LIPOTROPIN - ENDOGENOUS POTENT ANALGESIC PEPTIDE [J].